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Wednesday, September 1, 2010

Research teams from the universities of Georgia and Glasgow discovered the mechanism the Trypanosome parasite evolved for “sleeping sickness” disease to circumvent the human immune system. Their study follows a recent African outbreak of the disease this parasite causes. The discovery is expected to help develop a cure preventing future deaths.

The 1998–2001 sleeping sickness epidemics in South Sudan, Angola, Democratic Republic of Congo, and Uganda caused tens of thousands of deaths. The parasites are spread by tsetse flies. It is considered one of the worst epidemics in the last five decades. As WHO reported, subsequent recent introduction of population screening in rural areas and distribution of more effective drugs had potentially reduced the number of death incidents. However, the main effect of these measures being a decrease in spreading of the parasite and not in decrease of the death rate, the researchers decided to tackle the puzzle.

The scientists studied the molecules the human immune system activates in response to the attack. They were looking for the way the parasites inhibit it and lead to the death of the victim. Of the several known parasite species, the two that can infect humans were chosen to study, called Trypanosoma brucei gambiense and Trypanosoma brucei rhodensiense. Several others also exist, but they affect only animals.

Researchers knew that the Trypanosoma attacks typically are repelled by an HDL, more specifically trypanosome lytic factor-1 (TLF-1). It is generated in the humans’ immune system and is toxic to the parasites but not to humans. It was known that one of the parasites, T. b. rhodensiense, has evolved an inhibitor of the toxic chemical, called Serum Resistance Associated (SRA) protein. However the other one, T. b. gambiense, was responsible for over 95% of human deaths, and it had been previously unknown why.

The study showed that a gene mutation has lead to a change in the parasite’s surface protein receptor. It doesn’t bind to TLF-1 as well as for other species, leading to a substantial decrease in TLF-1 uptake by the parasite. The receptor is more strict, causing a lower nutrient intake as well, but it suffices, and the parasite defends against the human immune system.

As professor and head of the department of biochemistry and molecular biology at UGA (and one of the leaders of the research) Stephen Hajduk explained, “Humans have evolved TLF-1 as a highly specific toxin against African trypanosomes by tricking the parasite into taking up this HDL because it resembles a nutrient the parasite needs for survival. But T. b. gambiense has evolved a counter measure to these human ‘Trojan horses’ simply by barring the door and not allowing TLF-1 to enter the cell, effectively blocking human innate immunity and leading to infection and ultimately disease.”

Based on the results of the research, humans could possibly develop a defense mechanism to keep the parasites from evading the human defense system. Stephen Hajduk commented, “We believe this research represents a paradigm shift and causes us to think more broadly about how pathogens avoid host defense mechanisms. It turns out that African trypanosomes have evolved a diversity of ways to avoid human innate and acquired immune systems.”

Wednesday, March 9, 2011

Alberto Granado Jiménez, the Argentinian biochemist who was Che Guevara’s companion on his transformative motorcycle trip through South America, died in Havana on Saturday, reported Cuban state television. He was 88 and died of natural causes.

The politically active Jiménez met Ernesto “Che” Guevara, then a medical student, in Hernando, Argentina where Guevara had gone to play rugby. Both were intellectually curious and interested in exploration. In 1951 they set out on an eight-month motorcycle trip through South American that exposed them to the poverty in which most South Americans lived. The pair worked in a leprosy colony and met wtih destitute miners and indigenous people. Both men kept diaries which served as the basis for the 2004 film, The Motorcycle Diaries, produced by Robert Redford and directed by Walter Salles.

According to the Guardian, “Their road trip awoke in Guevara a social consciousness and political convictions that would turn him into one of the iconic revolutionaries of the 20th century.” The trip is widely believed to have inspired Guevara to go to Cuba and join Fidel Castro in his 1959 revolt against Cuban dictator Fulgencio Batista.

By the time the two men met again eight years later, Guevara was a revolutionary hero and chief of Cuba’s central bank. Jiménez, who had remained in Argentina working in a clinic, accepted Guevara’s invitation to move to Cuba in 1961 and founded a medical facility in Santiago. Later he moved to Havana where he continued his medical work. The two remained friends although they did not always agree. Jiménez rejected Guevara’s belief that social reform in Latin America had to be accomplished through guerrilla warfare.

The book The Motorcycle Diaries was published in the 1990’s. Jiménez said of the book that it inspired the image of the young Che as a romantic figure.

Jiménez authored the book Traveling with Che Guevara: The Making of a Revolutionary, published in 2003.

Wednesday, May 19, 2010

The Internet has already brought great things to the world, but has also brought spam, phishing, scamming, etc. We all have seen them across the Internet. They promise money, weight loss, or other things a person may strive for, but they usually amount to only a lighter pocket. Online advertising has become something that the increasingly Internet-reliant society has become used to, as well as more aware of. As this is true, online ads have become more intricate and deceptive in recent years.

However, a certain type of advertisement has arisen recently, and has become more deceptive than any other Internet ad, and has tricked many users into credit card charges. These sites claim to be news websites that preach a “miracle product”, and they offer a free trial, and then charge the user’s credit card a large amount of money without informing them after the trial ends. These sites appear to be operating under one venture and have caught ad pages of high-traffic websites by storm. In this report, Wikinews’ Tjc6 investigates news advertisement sites.

These Internet ads work in different ways:

Hypothetically speaking, a reader is browsing the web, and then happens to come across something that they believe is too good to be true. A link on one of these high-traffic pages promises white teeth, weight loss, or huge profits from working at home part-time. Out of curiosity, they click on the link.

This is the way that people are attracted to these fake news sites on the internet. The domain owners draw in customers by purchasing advertising on some of the World Wide Web’s most visited pages. Curious users click and are led to what they believe is a news article. From anti-aging to shedding weight, these “articles” from non-existant newspapers and television stations depict a skeptical news reporter trying a product because they were instructed to by a superior.

As the user reads on, they find that the “reporter” miraculously achieves significant weight loss, teeth whitening, or other general health and beauty improvement. The reporter states that the reader can get the same results as they did by using a “free trial” of the product.

Next, the user looks to the bottom of the page, where there seems to be a set of user comments, all of them praising the product or products that are advertised — this is where we first see something suspicious. Across several of these false articles, the comments appear to show the exact same text, sometimes with even the same usernames as other sites.

There is obviously some kind of correlation. Although this appears to be true, most users who purchase these products do not look at multiple versions of these similar pages of what appears to be a fast-growing network of interconnected fake news sites.

Once customers have convinced themselves into buying the product, they are led to a product (or products) website which promises a free trial for a very low price. What they do not know about this, however, is that they are giving their credit card data to a company that will charge it automatically after the trial ends. In about 14 days, the user receives a charge on their credit card for an excessive amount of money, usually from about $80 to $100 (USD). All attempts to contact these companies and cancel their shipments usually prove to be futile.

What these sites have is a large amount of legal copy located at the bottom of each site, stating their right to charge the user. This site, a fake news article claiming to offer teeth-whitening benefits, has several paragraphs of fine print, including this: “…Upon signing up for the 10 day trial membership you will be charged up to $4.97 depending on various shipping and initial offer promotions at that time but not more than $4.97 upon signing. If not cancelled, you will be charged $89.97 upon completion of the 10 day trial period. Monthly thereafter or 30 days from the original order date, the charge will reoccur monthly at a total of $89.97 until cancelled…,” the site says.

Practices like this have alerted the Better Business Bureau, an American organization that studies and reports on the reliability and practices of US businesses. In a press release, a spokesman from the BBB spoke out against sites like this. “Many businesses across the country are using the same selling model for their products: They lure customers in with claimed celebrity endorsements and free trial offers, and then lock them in by making it extremely difficult to cancel the automatic delivery of more products every month…,” said the report that denounced the websites.

When a user looks at several of these sites, they notice that all of them have the same exact structure. Because of this, Wikinews decided to look into where some of the domains were owned, and if they were all in fact part of one company.

However, the results that Wikinews found were ones that were not expected. Out of the three random websites that were found in Internet ads, all using similar designs and methods to attract the customers, came from three different locations in three countries and two separate continents. The first came from Scottsdale, in the United States, while the next two came from Vancouver and Hamburg. There is no location correlation, but surely, there has to be something that connected these sites together. We had to look even further to try to find a connection.

There is some correlation within the product’s contact information. A large amount of the teeth-whitening products analyzed actually shared the same phone number, which lead to a distribution center located in St. Petersburg, Florida, and several other similar distribution centers located across the Southern United States. But, that explains only one of the categories of products that these websites cover, teeth whitening.

What about the other products? The other products such as weight loss and work-at-home kits all trace back to similar distribution centers in similar places. So, what do we make of all of this?

There is obviously some company that promotes these products through the fake news advertisements, but that company is nowhere to be found on the websites. All contact information is given on the product pages, and websites are copyrighted under the name of the domain, not a company. Whatever company has been the setup for these pages has been very good at hiding themselves from the Internet, as there is no information across the web about that mysterious large advertiser.

As a result of customers buying the products and having unauthorized charges on their credit cards, a large volume of complaints are currently present on awareness sites, complaint sites, and even the Better Business Bureau. Several customers point out that they were not informed of the steep charges and the company made it extremely difficult to cancel their subscription, usually resulting in the loss of several hundred dollars.

• “The trial offer was to pay for $3.95 for the cost of the shipping for one bottle. I noticed shortly after placing the order I had a charge on my credit card for $149.95. Unknown to myself the company charges for a membership if you don’t cancel within 14 days, I cancelled within 18 days…When I called the customer service number they told me the decision has been made and my refund request was denied. When I questioned the person on the other line about what I was getting for my $149.95 she told me I was not getting anything because I cancelled the membership.“

?“Tamara”, in a post to the Ripoff Report

• “This is a “free sample” scam: Pay only postage and handling and get a free sample of a tooth whitening system, they say. I looked for the “catch,” something that would indicate that there’d be hidden or recurring charges, but didn’t see anything, and ordered. Sure enough, a couple of weeks later, I see a charge for $88.97 on my bank statement…When I called, the guy answering the phone had obviously answered the same angry question many, many times: “Why has your company charged $88.97 to my card?” “Because you didn’t cancel your subscription in time,” he said tiredly.“

?“Elenor”, in a post to the Ripoff Report

One notable lawsuit has occurred as a result of these articles. Some of the articles about work at home kits specifically advertise things like “work for Google”, or “job openings at Google”. However, Google asserts these claims as false and has taken the case to court, as it is a copyright violation. “Thousands of people have been tricked into sending payment information and being charged hidden fees by questionable operations,” said Google in a statement.

The BBB has received over 3,000 complaints about products such as the ones that Google took offense to. The lawsuit has yet to begin in court, and no date has been set.

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Friday, September 9, 2005

New Orleans, Louisiana —After Category 4 storm Hurricane Katrina slammed into New Orleans, on the night before August 29, 2005, several flood control constructions failed. Much of the city flooded through the openings. One of these was the flood wall forming one side of the 17th Street Canal, near Lake Pontchartrain. The U.S. Army Corps of Engineers (USACE) is the primary agency for engineering support during such emergencies. A USACE team was assessing the situation in New Orleans on the 29th, water flow was stopped September 2nd, and the breach was closed on September 5th.

Friday, November 13, 2009

Wikinews interviewed author Marc Headley about his new book Blown for Good, and asked him about life inside the international headquarters of Scientology known as “Gold Base“, located in Gilman Hot Springs near Hemet, California. Headley joined the organization at age seven when his mother became a member, and worked at Scientology’s international management headquarters for several years before leaving in 2005.

Wednesday, November 22, 2006

The New Zealand National party has announced that it will pay back the GST (Goods and Services Tax) it owes to five different advertisers, all television stations, by buying advertising time for the several different charities. The advertisements will appear on the owed media outlets. They have decided with the current path is it would “unlawful” to pay back the GST normally.

The GST amounted to NZ$112,000.

National’s original plan of getting a one time bill passed that it would allow them to pack the owed GST to the media outlets was ditched in favour of this new one. “With the prospect of legislation diminishing, it’s time to accept that National cannot go down that path,” Judy Kirk, president of the National party, said.

If National was to pay back the GST, they would be breaking the law by going over the electioneering cap set by the Broadcasting Act.

The owed media companies are TVNZ, TV3 and Sky Television. It also includes Sky’s free-to-air channel, Prime.

Ms Kirk said: “We want to get some closure on the matter and have taken extensive legal advice on our options… We have secured clear advice that it would be unlawful to pay the five outstanding media creditors, and that it would be unlawful for them to accept payment. We do not wish to break the law, and nor do we wish to place our creditors in the position of breaking the law.”

“…we will purchase the media advertising time directly from broadcasters and ask that they allocate it amongst the range of charities currently supported by each,” Ms Kirk said.

National said that their error on not paying for the GST did not effect the outcome of the election, unlike the Labour party’s overspending.

Tuesday, October 2, 2007

Tad Brudzinski is running for the Family Coalition Party in the Ontario provincial election, in the Newmarket-Aurora riding. Wikinews’ Nick Moreau interviewed him regarding his values, his experience, and his campaign.

He did not answer the question “Of the decisions made by Ontario’s 38th Legislative Assembly, which was the most beneficial to your electoral district? To the province as a whole? Which was least beneficial, or even harmful, to your riding? To the province as a whole?”

Stay tuned for further interviews; every candidate from every party is eligible, and will be contacted. Expect interviews from Liberals, Progressive Conservatives, New Democratic Party members, Ontario Greens, as well as members from the Family Coalition, Freedom, Communist, Libertarian, and Confederation of Regions parties, as well as independents.